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Best Vertical Mice to Prevent Wrist Strain and Joint Pain [2021]

Having a mouse with improved performance and smoother controls might reduce physical tension, but it doesn’t reduce stress. Recent years have seen the arrival of several ergonomic models that are quite good in performance. Their design aims to relieve shoulder, wrist, finger, and even neck pain.

For people suffering from severe wrist pain or carpal tunnel syndrome, an ergonomic mouse isn’t sufficient. So let’s ditch the traditional mouse and go vertical.

The vertical gaming mice are now proving to be the most ergonomic and the most comfortable, so they are worth the money for office workers, professional photo editors, graphics designers, gamers, and programmers.

Why Use a Vertical Mouse?

Because vertical mice conform to the shape of your hand, they are designed with handshake grip in mind. Based on the handshake grip concept, they incorporate relevant ergonomic features. A vertical mouse is the next mouse for gamers and office workers who have already used ergonomic mice but still experiencing physical pain in their hands and wrists.

If you have pain in your fingers, wrists, forearms, and elbows, consider a vertical mouse. While it may take some time to adjust to these models, the health benefits are higher than traditional models.

Top 7 Best Vertical Mice in 2021

There aren’t many gaming brands producing ergonomic mice. It’s rather difficult to tell the difference between affordable options that are excellently designed and nothing more than cheap plastic. Our 48-hour research has resulted in the seven best vertical mice that are ergonomic in shape and deliver impressive performance at an affordable price. 

1. Logitech MX Vertical Mouse

Logitech MX Vertical Mouse

You may already know about Logitech MX Vertical if you have already seen our article on the best ergonomic mice. Don’t think this is just a vertical mouse; rather, it is a beautifully shaped ergonomic mouse that you would love because of its unmatched performance and the highest comfort level, thanks to its natural grip that will lessen carpal tunnel issues.

To ensure healthy gaming, the natural grip and perfect posture ultimately reduce wrist stress. This device offers many physical benefits due to its unique 57-degree grip design. 

The 57 degree angle promotes a natural handshake, reducing muscle strain and forearm bending. You will feel as if the mouse is built for you once you have added the textured rubber grip. That’s why you won’t let the MX Vertical go, no matter what. 

The MX Vertical wouldn’t have made our list just because of its comfort; rather, its exact 4,000 DPI settings and outstanding accuracy make it the best vertical mouse for gaming. You can make precise movements even when you have a high load of graphics with this DPI range.

Because the MX Vertical is a wireless model, it is rechargeable, and it can function for three hours on a single charge.

The Logitech MX Vertical is the best ergonomic mouse you can use for gaming and the office. 

  • Ability to switch between three PCs
  • Offers an incredible four months of playtime on a single charge
  • Prone to dust and debris
  • Doesn’t fit all hand sizes

2. Jelly Comb MV09F Vertical Mouse

elly Comb MV09F Vertical Mouse

Another mouse for smaller hands. With its perfect fit and adaptable design, the Jelly Comb Wireless is a perfect addition to your gaming rig. 

The Jelly Comb naturally blends design and functionality, unlike many smaller mice that sacrifice design for durability. It may not have many features, but it has enough to be useful.

Although its design is unconventional, the Jelly Comb reaches the handshake position naturally with a rounded shell at an open angle as opposed to using a vertical extension. Compared to the rest of the features offered by this mouse, the natural position is the most promising. 

For the price point, the company probably added limited features and customization options. Nevertheless, you can customize mouse sensitivity with built-in DPI presets. 

The mouse has a compact design, but it requires bulky AA batteries, making it a bit heavy. This is without a doubt the best mouse for smaller-handed gamers; however, the mice in this category don’t qualify as high-end gaming mice. The Jelly Comb cannot offer gaming performance above the middle level because of this. 

The price and comfort are both features that make it a worthwhile ergonomically designed mouse. Please keep in mind, however, that this is not the best mouse for gaming, and you may face serious limitations due to its limited features.  

  • Inexpensive model
  • Best for small-handed persons
  • Limited sensitivity customization options
  • Wireless play requires batteries

3. J-Tech Digital Optical Mouse

J-Tech Digital Optical Mouse

Vertical gaming mice aren’t that common. Often, these mice are either geared toward comfort or designed to pass off as gimmicks. Even though the J-Tech Vertical mouse has a lower price point, it is still a good vertical mouse you should own.

Plug-and-play makes it a great advantage for you. Featuring a simple, clear, and ergonomic design that combines traditional gaming flair with a touch of class. Moreover, the mouse features a removable palm rest to relieve wrist pain if your hand is always hanging off the mouse.

The mouse lets you choose between three DPI settings for gaming: 800, 1,200, and 1,600. This mouse has a response rate of 125 Hz and well-positioned thumb buttons, despite not offering the most customization options. Furthermore, there are two sizes of the mouse, one specifically designed for smaller hands.

Despite its limitations, the J-Tech is an affordable, ergonomic gaming mouse that makes a great alternative to the traditional best gaming mice that allow you to customize and remap the entire device. Built well, easy to use, and lasts for years as long as the ergonomic features work for you. 

This mouse has a number of drawbacks, including a cheap scroll wheel and a non-grippy exterior that may cause inconvenience in a comfortable gaming environment.

  • Removable ergonomic palm rest
  • Availability of Multiple size options
  • Scroll wheel isn’t durable
  • No customization options

4. Logitech MX Master Mouse

Logitech MX Master Mouse

While it is not a vertical mouse, the MX Master is a good option to consider if you want something ergonomic for gaming. Logitech was the first company to introduce a vertical mouse with its MX Vertical. Initially, they focused on making vertical/ergonomic hybrids that could be customized and had better battery life. In many ways, the MX Master is like the older brother of the MX Vertical, with a few more features and less specialization.

Feel-wise, it’s one of the best hybrid mice on the market, much like its predecessor Logitech G Pro X Superlight. The ergonomic shape makes it easy to grip the device ergonomically without any difficulty. As a result of the polygonal thumb rest, it appears to be a hybrid design with both horizontal and vertical elements.

In terms of button placement, Logitech paid special attention to comfort and performance. The buttons are close enough to the lip that they can be reached easily, but far enough away to prevent accidental misclicks. Smooth and comfortable primary keys provide tactile feedback with every click. This nice design, perfect clicks, and efficient grip will ultimately improve your gaming performance significantly.

There are two speed-oriented scroll wheels on the mouse: one is a primary wheel and the other a thumb wheel. By allowing the gamer to change between free-spinning and accurate click-to-click modes, both wheels nicely respond to pressure applied while scrolling.

A single charge of the mouse can hold battery life for up to 40 days while not in use due to its excellent battery life. These metrics are based on intensive mouse use and may vary based on usage.

Every product has some unavoidable shortcomings, and the Logitech MX Master is no exception. Even though the hybrid design is stylish and innovative, it takes some getting used to.

In conclusion, it might be easy to find the Vertical option, but the Logitech MX Master is still a good choice if you prefer a bulky ergonomic mouse for bigger hands.

  • Well-positioned buttons and scroll wheels
  • Ergonomic design and thumb rest
  • Not a fully vertical design
  • Expensive

5. MOJO Silent Vertical Mouse

MOJO Silent Vertical Mouse

The majority of today’s mice emit an audible click when clicked, so finding a truly silent mouse can be difficult. Unlike most gaming mice, the MoJO Silent vertical is an exceptionally silent mouse.

The mouse’s silence can be explained by several factors. Yet, its ergonomic vertical shape, lightweight casing, and unique “silent buttons” make it the best ergonomic mouse for office work and graphics designing. You can glide the mouse across a smooth mousepad, click furiously, and make intensive scrolls silently with a smooth mousepad.

While its silent gimmick makes this mouse special, it falls short of the praise it deserves. A large part of its perfection can be attributed to the typical mouse size and the location of buttons.

Although the handshaking grip is intended to benefit, the mouse’s middling size and high-positioned thumb controls make it difficult to use. This placement of buttons, however, makes the mouse more usable and precise for people with small hands. However, the awkward button placement may seriously hinder the performance of persons with large hands, even if the six buttons offer a greater degree of customization and flexibility. 

MoJO Silent Vertical is a good mouse to buy if you have small or medium hands. With the mouse, you’ll get silent clicks and a high level of productivity at an affordable price. A short-handed entry-level gamer looking for the best balance of performance, ergonomics, and price should consider this mouse.

  • Bluetooth connectivity for Mac users
  • Silent buttons and mouse movement
  • Not for large hands
  • Not much ergonomic

6. TRELC Ergonomic Vertical Mouse

TRELC Ergonomic Vertical Mouse

The TRELC vertical gaming mouse stands out from the rest due to its strong wired design. Based on the features and performance it delivers, it is certainly worth buying. The 5D Rocker joystick features thumb-controlled movement in five directions: front, back, left, right, and down. It is for this reason that the mouse is ideal for MOBA, FPS, MMO, and other games. 

Second, there are 11 programmable buttons for all advanced gestures, so you can remap the entire mouse according to your preferences.

TRELC’s mouse also offers a range of DPI settings, from a modest 1500 DPI to a stunning 10,000 DPI. Due to the speed customization feature, you can use this mouse for both office work and gaming. 

Additionally, it has a photoelectric game chip and 128 KB of built-in memory to save game presets, and 20-G acceleration for the highest level of precision.

However, the mouse is not recommended for turn-based strategy games like Civilization VI and Gear Tactics. Two, the DPI settings are only the pre-installed ones, which you cannot change. This is why this mouse is usually recommended for mid-level gaming. Lastly, the software has a major bug and asks for administrator access on every restart, which makes it quite difficult to use.

  • The mouse wheel is nicely built for weapon swapping
  • 100 IPS move speed
  • 20 G acceleration
  • Not for lefties
  • DPI settings cannot be modified
  • Not recommended for turn-based strategy games

7. Evoluent VerticalMouse 4

 Evoluent VerticalMouse 4

Evoluent has steadily enhanced its signature models over the past few years, becoming a market leader. VM4R, now in its fourth generation, has the look, feel, and price of a premium mouse.

The superb ergonomics and superb build quality of this wired vertical mouse have already earned it a legendary reputation among enthusiasts. 

Evoluent’s software bundle, Evoluent Mouse Manager, lets you customize the mouse buttons and DPI settings to suit your needs. An important feature of this vertical mouse is its ergonomic vertical design, which makes it easy and comfortable to use for the whole day while browsing the web. The handshake posture offers a natural grip that relieves wrist and hand pains and lessens stress on sensitive nerves.

The front side has the traditional buttons: left/right, middle, and a scroll wheel, while the rear side has the forward/backward buttons close to the thumb. There is also a mouse sensitivity button on its thumb side.

It’s one of the few Mac-compatible vertical mice with a driver. You can reprogram and customize the mouse driver according to your needs, thus avoiding incompatibility issues common to most.

In addition, the Evoluent Vertical Wireless mouse relies on Bluetooth instead of a USB dongle. The USB-C connector is the perfect addition to laptops in these days when USB-A is disappearing.

We really like this Evoluent because it offers a wide variety of choices based on the usage. The same is true for VM4, which has a right-handed and a left-handed version. Furthermore, the mouse is available with a VM4R Wireless model for Windows users and an Evoluent VM4R Bluetooth model for Mac users. Depending on the model, the price may vary.

Although the Evoluent VM4R isn’t an all-in-one vertical mouse, it can be used with almost all laptops and PCs. For those requiring the highest ergonomics and productivity at a premium price, this is the best vertical mouse.

  • Allows on the fly DPI settings
  • Plug-and-play capability
  • Best for Mac users
  • Prone to smudging
  • Bulky and Heavy

Buyer’s Guide for Vertical Mice


Similar to the broader ergonomic mouse category, it can be challenging to wade through various vertical mice. Most of them have similar price tags, look similar, and claim to be natural handshake solutions. By considering the following points, you’ll be able to narrow down your search for the right vertical mouse.

1. Size and Comfort

You can’t call a mouse ergonomic if it doesn’t fit in your hand. You can customize the contours of the vertical mouse by using its removable finger rests or ridged grip, but if the mouse doesn’t fit in your hand due to its size, you will struggle with it. This is why you should start here.

Learn about your options. Consider how the mouse’s size and weight may affect your ability to use the mouse comfortably. Make sure the buttons are easily accessible by considering where they are placed. Follow these guidelines by Moir Ortho to avoid similar injuries in the future.

2. Wired vs. Wireless

In the vertical mice category, both wired and wireless mice are available. Unfortunately, most vertical mice are not gaming-oriented; instead, they are often wireless. Now it is up to you for what purpose you are buying this mouse. 

3. Performance

Next, you need to look at the performance of the vertical in the real world. I want to remind you once again that the vertical mice are not designed for high-level precision. They have average sensitivity presets, mediocre performance, and limited customization options.

This is why you should think carefully before selecting a gaming mouse, since a mouse with limited gaming features can seriously affect your gaming performance. 

4. Connectivity

A vertical mouse can be connected to your PC via wire, Bluetooth, or a USB dongle, just like a standard mouse.

For each type, there is an advantage and a disadvantage. Wired mice tend to be more responsive, faster, and require no batteries, but the cable can be a drawback.

Wireless mice are more flexible than wired mice, allowing you to move them around freely. Their responsiveness and sensitivity tend to be less than wired models, and if powered by disposable batteries, the batteries may need to be replaced every few months.

5. Power and charging.

Purchasing a mouse that uses rechargeable batteries requires you to consider whether it can be used while charging, how long it will take to fully charge, and how long it will be in use.

Power-saving modes are also available for mice with disposable batteries to extend the life of the batteries when they are not being used.

6. Sensitivity

You might like a mouse that lets you adjust the pointer’s speed if you do tasks that require speed or precision, such as gaming.

DPI (dots per inch) is used to measure mouse sensitivity. DPI settings allow the mouse cursor to be more responsive, responding to movements as small as a mouse click. Most vertical mice have a DPI switch for adjusting the sensitivity.

7. Buttons

Most vertical mice have four buttons: right, left, a scroll wheel, and forward/back. In contrast, some of the best vertical mice come with four to six extra buttons and software to customize them. Using common shortcuts is easy, including copying and pasting, which usually takes a few clicks.

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People who use an improperly constructed mouse frequently complain about wrist strain, carpal tunnel, and physical pain. For this reason, you need a health-friendly, vertical mouse that makes sure that you are having a good time while using the PC.

In order to reduce wrist strain and make healthy yet mediocre gaming, vertical mice are the best choice you can make at a reasonable price.

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